Journal
INTERNAL MEDICINE JOURNAL
Volume 44, Issue 3, Pages 287-290Publisher
WILEY
DOI: 10.1111/imj.12363
Keywords
immunosuppression; biologicals; psoriasis; hepatosplenic T-cell lymphoma; inflammatory bowel disease
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We present three cases of the rare hepatosplenic T-cell lymphoma (HSTCL); two patients suffering from Crohn disease who developed HSTCL on azathioprine without exposure to biologicals, and a third patient who had psoriasis treated using etanercept, cyclosporine and methotrexate. The evidence for an association between HSTCL and immunosuppressive drugs and biologicals is reviewed. We argue for improved pharmacovigilance processes to help determine the benefit to risk ratios for the use of these and other new agents.
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