Journal
INTERNAL MEDICINE JOURNAL
Volume 41, Issue 11, Pages 795-797Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1445-5994.2011.02580.x
Keywords
prosthetic valve endocarditis; neurologic complication; anticoagulation; thromboembolism; haemorrhage
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Funding
- NHMRC Centre for Clinical Research Excellence (CCRE) Clinical Science in Diabetes
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The use of anticoagulant therapy in prosthetic valve endocarditis is a controversial management issue. Some authorities believe that anticoagulation increases the potential risk of cerebral haemorrhage after a thromboembolism whereas others, however, affirm that cessation of anticoagulation itself increases the risk of thromboembolism and subsequent morbidity and mortality. We reviewed the association of anticoagulant therapy and cerebral complications in patients with prosthetic valve endocarditis. Our results suggest that anticoagulant therapy reduces the risk of thromboembolism and is not associated with increased risk of intracranial haemorrhage.
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