Journal
INTERNAL MEDICINE
Volume 53, Issue 16, Pages 1791-1795Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.53.1646
Keywords
GLP-1; hypothalamus; hyperphagia; obesity; satiety
Categories
Ask authors/readers for more resources
Hypothalamic hyperphagia and obesity are characterized by a lack of satiety and an abnormally high appetite that is difficult to control. We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabetes mellitus associated with an abnormal eating behavior and weight gain. Liraglutide was successfully used to treat their diabetes mellitus and suppress their abnormal appetites. Glucagon-like peptide-1 analogues, including liraglutide, are promising treatment options in patients with hypothalamic hyperphagia and obesity, as these agents enhance the hypothalamic input of the satiety signal, which is lacking in such patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available