Journal
INTERNAL MEDICINE
Volume 50, Issue 6, Pages 611-615Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.50.4640
Keywords
systemic mastocytosis; omalizumab; tryptase
Categories
Ask authors/readers for more resources
We report on the outcome of 4 patients with therapy-resistant systemic mast cell activation disease (MCAD) treated with the anti-IgE monoclonal antibody omalizumab in compassionate use. Two patients achieved an impressive persistent clinical response to treatment with omalizumab. In the third patient symptoms gradually improved. In the fourth patient omalizumab treatment had to be discontinued due to intolerable mast cell mediator-induced symptoms. In conclusion, omalizumab can lessen the intensity of the symptoms of systemic MCAD. Hence, omalizumab should be considered as a therapeutic option in cases of systemic MCAD that are resistant to evidence-based therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available