Journal
INTERNAL MEDICINE
Volume 48, Issue 12, Pages 1037-1039Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.48.1990
Keywords
pioglitazone; slowly progressive type 1 diabetes; PPAR-gamma; anti-GAD antibody
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Although recent studies recommended that insulin should be administered to patients with slowly progressive type 1 diabetes, even those with non-insulin dependent status, patients prefer oral hypoglycemic agents to insulin injections. We report a slowly progressive type 1 diabetic patient whose insulin production was preserved for 4 years (Sigma C-peptide from 29.48 ng/mL to 24.58 ng/mL) using pioglitazone despite a high titer of anti- GAD antibody (GADA; 120.7 U/mL). This case suggests that pioglitazone might prevent or delay the loss of insulin secretion and insulin dependency in slowly progressive type 1 diabetic patients.
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