Journal
INTEGRATIVE CANCER THERAPIES
Volume 13, Issue 1, Pages 38-45Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735413490235
Keywords
radiotherapy; radiation therapy; oncology; radiodermatitis; skin fibrosis; antioxidants; polyphenol; flavone
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Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.
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