4.2 Review

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

Paul M. van Midwoud et al.

ANALYTICAL CHEMISTRY (2011)

Review Biotechnology & Applied Microbiology

In vitro microscale systems for systematic drug toxicity study

Jong Hwan Sung et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2010)

Article Biochemical Research Methods

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

Cheul H. Cho et al.

BIOTECHNIQUES (2010)

Article Biotechnology & Applied Microbiology

Microfluidic Biochip for the Perifusion of Precision-Cut Rat Liver Slices for Metabolism and Toxicology Studies

Paul M. van Midwoud et al.

BIOTECHNOLOGY AND BIOENGINEERING (2010)

Review Biochemical Research Methods

Integration and detection of biochemical assays in digital microfluidic LOC devices

Lidija Malic et al.

LAB ON A CHIP (2010)

Article Biochemical Research Methods

Perfused multiwell plate for 3D liver tissue engineering

Karel Domansky et al.

LAB ON A CHIP (2010)

Article Gastroenterology & Hepatology

Optimization of the Cryopreservation and Thawing Protocol for Human Hepatocytes for Use in Cell Transplantation

Claire Terry et al.

LIVER TRANSPLANTATION (2010)

Article Biotechnology & Applied Microbiology

Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity

Gretchen J. Mahler et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Review Medical Laboratory Technology

Toxicity testing: the search for an in vitro alternative to animal testing

J. E. May et al.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2009)

Article Biotechnology & Applied Microbiology

Interaction between hepatocytes and collagen gel in hollow fibers

Jing Dai et al.

CYTOTECHNOLOGY (2009)

Review Biochemistry & Molecular Biology

Liver tissue engineering in the evaluation of drug safety

Ajit Dash et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)

Review Biochemistry & Molecular Biology

Bile acids: regulation of synthesis

John Y. L. Chiang

JOURNAL OF LIPID RESEARCH (2009)

Article Biochemical Research Methods

A microfluidic chip for electrochemical conversions in drug metabolism studies

M. Odijk et al.

LAB ON A CHIP (2009)

Article Biochemical Research Methods

A microfluidic 3D hepatocyte chip for drug toxicity testing

Yi-Chin Toh et al.

LAB ON A CHIP (2009)

Article Medicine, Research & Experimental

TGF-β1 Gene Silencing for Treating Liver Fibrosis

Kun Cheng et al.

MOLECULAR PHARMACEUTICS (2009)

Article Cell & Tissue Engineering

Perfusion Cell Seeding and Cultivation Induce the Assembly of Thick and Functional Hepatocellular Tissue-like Construct

Irena Shvartsman et al.

TISSUE ENGINEERING PART A (2009)

Review Chemistry, Analytical

Cell Culture Models in Microfluidic Systems

Ivar Meyvantsson et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY (2008)

Article Engineering, Biomedical

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

Amedeo Carraro et al.

BIOMEDICAL MICRODEVICES (2008)

Review Biochemistry & Molecular Biology

Studying cytochrome P450 kinetics in drug metabolism

Melissa A. Kramer et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

Review Biochemistry & Molecular Biology

Evolving concepts in liver tissue modeling and implications for in vitro toxicology

Andre Guillouzo et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

Review Biochemistry & Molecular Biology

An update on metabolism studies using human hepatocytes in primary culture

Maria Jose Gomez-Lechon et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

Review Chemistry, Medicinal

Pharmacokinetics in drug discovery

Ana Ruiz-Garcia et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Article Biochemical Research Methods

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies

Samantha M. Hattersley et al.

LAB ON A CHIP (2008)

Article Toxicology

A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine

Annalisa Tirella et al.

TOXICOLOGY IN VITRO (2008)

Article Engineering, Biomedical

Microfluidic environment for high density hepatocyte culture

Mimi Y. Zhang et al.

BIOMEDICAL MICRODEVICES (2008)

Article Biotechnology & Applied Microbiology

Microscale culture of human liver cells for drug development

Salman R. Khetani et al.

NATURE BIOTECHNOLOGY (2008)

Review Biochemistry & Molecular Biology

Precision-cut tissue slices as a tool to predict metabolism of novel drugs

Inge A. M. de Graaf et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)

Article Biotechnology & Applied Microbiology

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

Philip J. Lee et al.

BIOTECHNOLOGY AND BIOENGINEERING (2007)

Review Biochemical Research Methods

A practical guide to microfluidic perfusion culture of adherent mammalian cells

Lily Kim et al.

LAB ON A CHIP (2007)

Article Biochemistry & Molecular Biology

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates

Srivatsan Kidambi et al.

MACROMOLECULAR BIOSCIENCE (2007)

Article Engineering, Biomedical

A microfluidic platform for 3-dimensional cell culture and cell-based assays

Minseok S. Kim et al.

BIOMEDICAL MICRODEVICES (2007)

Article Biochemical Research Methods

Cell-based high content screening using an integrated microfluidic device

Nannan Ye et al.

LAB ON A CHIP (2007)

Article Biochemical Research Methods

A novel 3D mammalian cell perfusion-culture system in microfluidic channels

Yi-Chin Toh et al.

LAB ON A CHIP (2007)

Review Toxicology

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

Ruth A. Roberts et al.

TOXICOLOGICAL SCIENCES (2007)

Article Cell & Tissue Engineering

Perfusion culture improves the maintenance of cultured liver tissue slices

Karl Schumacher et al.

TISSUE ENGINEERING (2007)

Article Cell & Tissue Engineering

Novel intra-tissue perfusion system for culturing thick liver tissue

Yuet Mei Khong et al.

TISSUE ENGINEERING (2007)

Article Biochemical Research Methods

PDMS absorption of small molecules and consequences in microfluidic applications

Michael W. Toepke et al.

LAB ON A CHIP (2006)

Article Chemistry, Analytical

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

Bartholomew J. Kane et al.

ANALYTICAL CHEMISTRY (2006)

Review Cell Biology

Capturing complex 3D tissue physiology in vitro

LG Griffith et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Review Biotechnology & Applied Microbiology

Lab-on-a-chip: microfluidics in drug discovery

PS Dittrich et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biotechnology & Applied Microbiology

Identity tests: determination of cell line cross-contamination

C. M. Cabrera et al.

CYTOTECHNOLOGY (2006)

Article Pharmacology & Pharmacy

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

C Aninat et al.

DRUG METABOLISM AND DISPOSITION (2006)

Review Biochemistry & Molecular Biology

A microscale in vitro physiological model of the liver:: Predictive screens for drug metabolism and enzyme induction

A Sivaraman et al.

CURRENT DRUG METABOLISM (2005)

Article Engineering, Biomedical

Microreactor microfluidic systems with human microsomes and hepatocytes for use in metabolite studies

JC Zguris et al.

BIOMEDICAL MICRODEVICES (2005)

Article Biochemical Research Methods

A configurable three-dimensional microenvironment in a microfluidic channel for primary hepatocyte culture

YC Toh et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2005)

Article Biotechnology & Applied Microbiology

Development of a microscale cell culture analog to probe naphthalene toxicity

K Viravaidya et al.

BIOTECHNOLOGY PROGRESS (2004)

Article Biotechnology & Applied Microbiology

Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

K Viravaidya et al.

BIOTECHNOLOGY PROGRESS (2004)

Article Biotechnology & Applied Microbiology

Key factors in the rising cost of new drug discovery and development

M Dickson et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Review Pharmacology & Pharmacy

Strategies for using in vitro screens in drug metabolism

N Plant

DRUG DISCOVERY TODAY (2004)

Review Pharmacology & Pharmacy

Early prediction of drug metabolism and toxicity: systems biology approach and modeling

A Bugrim et al.

DRUG DISCOVERY TODAY (2004)

Article Biotechnology & Applied Microbiology

Perfusion culture of fetal human hepatocytes in microfluidic environments

E Leclerc et al.

BIOCHEMICAL ENGINEERING JOURNAL (2004)

Article Engineering, Biomedical

Membrane-based PDMS microbioreactor for perfused 3D primary rat hepatocyte cultures

S Ostrovidov et al.

BIOMEDICAL MICRODEVICES (2004)

Review Engineering, Electrical & Electronic

A review of micropumps

DJ Laser et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2004)

Article Chemistry, Analytical

Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection

S Benetton et al.

ANALYTICAL CHEMISTRY (2003)

Review Pharmacology & Pharmacy

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

EFA Brandon et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Article Engineering, Biomedical

Cell culture in 3-dimensional microfluidic structure of PDMS (polydimethylsiloxane)

E Leclerc et al.

BIOMEDICAL MICRODEVICES (2003)

Article Cell Biology

Identification of HepG2 variant cell lines by short tandem repeat (STR) analysis

JF van Pelt et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2003)

Article Biochemical Research Methods

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

U Jurva et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2003)

Review Cell Biology

Progress in human hepatocytes: isolation, culture & cryopreservation

RR Mitry et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2002)

Review Biochemistry & Molecular Biology

Microchip-based high-throughput screening analysis of combinatorial libraries

J Khandurina et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2002)

Article Biotechnology & Applied Microbiology

A microfabricated array bioreactor for perfused 3D liver culture

MJ Powers et al.

BIOTECHNOLOGY AND BIOENGINEERING (2002)

Article Dentistry, Oral Surgery & Medicine

In vitro model of a vascular stroma for the engineering of vascularized tissues

B Frerich et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2001)

Article Biochemistry & Molecular Biology

TGFβ1 in liver fibrosis:: time to change paradigms?

M Bauer et al.

FEBS LETTERS (2001)

Article Biotechnology & Applied Microbiology

Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor

AW Tilles et al.

BIOTECHNOLOGY AND BIOENGINEERING (2001)

Review Pharmacology & Pharmacy

Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology

C Lerche-Langrand et al.

TOXICOLOGY (2000)

Article Chemistry, Multidisciplinary

Generation of solution and surface gradients using microfluidic systems

NL Jeon et al.

LANGMUIR (2000)

Article Chemistry, Multidisciplinary

Bioadsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery

MH Sheridan et al.

JOURNAL OF CONTROLLED RELEASE (2000)