Journal
INTEGRATIVE BIOLOGY
Volume 3, Issue 10, Pages 993-1002Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ib00026h
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Funding
- National Natural Science Foundation of China [30900291]
- China Postdoctoral Science Special Foundation [201003127]
- Natural Science Foundation of Guangdong Province [10451805702004178]
- Natural Science Foundation of Liaoning Province [20102055]
- Shenzhen Bureau of Science, Technology Information [JC200903180531A, JC201005270308A]
- Shenzhen Nanshan Science and Technology Program [KJ02S0210900000109]
- State Key Laboratory of Oncology in South China
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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The purpose of this research was to develop formulation of docetaxel-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles for breast cancer chemotherapy. A novel diblock copolymer, D-alpha-tocopheryl polyethylene glycol 1000 succinate-b-poly(epsilon-caprolactone-ran-glycolide) [TPGS-b-(PCL-ran-PGA)], was synthesized from epsilon-caprolactone, glycolide and D-alpha-tocopheryl polyethylene glycol 1000 succinate by ring-opening polymerization using stannous octoate as catalyst. The obtained copolymers were characterized by (1)H NMR, GPC and TGA. The docetaxel-loaded TPGS-b-(PCL-ran-PGA) nanoparticles were prepared and characterized. The data showed that the fluorescence TPGS-b-(PCL-ran-PGA) nanoparticles could be internalized by MCF-7 cells. The TPGS-b-(PCL-ran-PGA) nanoparticles achieved significantly higher level of cytotoxicity than commercial Taxotere (R). MCF-7 xenograft tumor model on SCID mice showed that docetaxel formulated in the TPGS-b-(PCL-ran-PGA) nanoparticles could effectively inhibit the growth of tumor over a longer period of time than Taxotere (R) at the same dose. In conclusion, the TPGS-b-(PCL-ran-PGA) copolymer could be acted as a novel and potential biologically active polymeric material for nanoformulation in breast cancer chemotherapy.
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