Journal
INTEGRATIVE BIOLOGY
Volume 2, Issue 5-6, Pages 229-240Publisher
OXFORD UNIV PRESS
DOI: 10.1039/c000442a
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Funding
- Korea Research Foundation Grant, Republic of Korea [KRF-2008-357-D00030]
- NRL (National Research Lab)
- Korea Science and Engineering Foundation (KOSEF), Republic of Korea [20090083115]
- NIH [R01 CA136829-01, R01 HL084370-04, R01 HG004653-02]
- NATIONAL CANCER INSTITUTE [R01CA136829] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL084370] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004653] Funding Source: NIH RePORTER
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Cells express hundreds of different types of receptors, which they use to continuously monitor their chemical and mechanical microenvironments. Stem cells and cancer cells are particularly sensitive to microenvironmental cues because their interactions have profound effects on stem cell potency and tumorigenesis, respectively. Unlike conventional tissue culture in wells and dishes, microtechnology with dimensions on the cellular scale can be combined with materials, chemicals, physiological flows, and other effectors to provide high levels of control in a format more flexible than macroscale in vitro or in vivo systems, revealing stimulation-specific responses of stem cells and cancer cells. Microtechnology-integrated biology enable the simultaneous control of multiple numbers of biological microenvironmental factors in a high-throughput manner. In this review we present representative examples of the use of microtechnology systems to regulate the mechanical, chemical, topological, adhesive, and other environments of individual stem cells and cancer cells. We then explore the possibilities for simultaneous multimodal control of combinations of these environmental factors.
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