Journal
INTEGRATIVE AND COMPARATIVE BIOLOGY
Volume 54, Issue 6, Pages 985-1000Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/icb/icu107
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Funding
- NHLBI NIH HHS [1 P01HL108808-01A1, 5 R01 HL077546-05, HL 41126, HL 85156, HL 84370] Funding Source: Medline
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1347346] Funding Source: National Science Foundation
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [1410047, 1412844] Funding Source: National Science Foundation
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Modeling the flow of fluid in the lungs, even under baseline healthy conditions, presents many challenges. The complex rheology of the fluids, interaction between fluids and structures, and complicated multi-scale geometry all add to the complexity of the problem. We provide a brief overview of approaches used to model three aspects of pulmonary fluid and flow: the surfactant layer in the deep branches of the lung, the mucus layer in the upper airway branches, and closure/ reopening of the airway. We discuss models of each aspect, the potential to capture biological and therapeutic information, and open questions worthy of further investigation. We hope to promote multi-disciplinary collaboration by providing insights into mathematical descriptions of fluid-mechanics in the lung and the kinds of predictions these models can make.
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