Journal
INTEGRATIVE AND COMPARATIVE BIOLOGY
Volume 53, Issue 2, Pages 319-328Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/icb/ict003
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Funding
- US National Science Foundation [DEB-1011349, DEB-0640690, IOS-0821130, MCB-0950896]
- Georgia Tech-Elizabeth Smithgall Watts endowment
- Society for Integrative and Comparative Biology Ecological Epigenetics Symposium
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0950896] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0821130] Funding Source: National Science Foundation
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Epigenetic inheritance plays a fundamentally important role in mediating gene regulation and phenotypic plasticity. DNA methylation, in particular, has been the focus of many recent studies aimed at understanding the function of epigenetic information in insects. An understanding of DNA methylation, however, requires knowledge of its context in relation to other epigenetic modifications. Here, we review recent insights into the localization of DNA methylation in insect genomes and further discuss the functional significance of these insights in the context of the greater eukaryotic epigenome. In particular, we highlight the complementarity of the eukaryotic epigenetic landscape. We focus on the importance of DNA methylation to nucleosome stability, which may explain the context-dependent associations of DNA methylation with gene expression. Ultimately, we suggest that the integration of diverse epigenetic modifications in studies of insects will greatly advance our understanding of the evolution of epigenetic systems and epigenetic contributions to developmental regulation.
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