Journal
INTEGRATIVE AND COMPARATIVE BIOLOGY
Volume 48, Issue 5, Pages 668-680Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/icb/icn048
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Funding
- NICHD NIH HHS [P01 HD022486] Funding Source: Medline
- NIDCR NIH HHS [R01 DE013834, K99 DE018088] Funding Source: Medline
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In most versions of theories of the segmentation of the vertebrate head, a premandibular segment is present rostral to the jaw-forming mandibular segment. These theories posit that in ancient fishes this segment included a gill and a gill-supporting skeleton, which then was modified to support the anterior brain. However, we find no recent evidence for existence of such a premandibular segment. Rather, new findings from studies of fate mapping and gene expression show that the premandibular territory is in fact the maxillary region of the mandibular arch. A signaling cascade, beginning with dorsal midline mesoderm in the gastrula and relayed through neural ectoderm and then oral ectoderm, greatly expands the skeletal derivatives of maxillary neural crest in a manner fully consistent with the GansNorthcutt theory of the vertebrate new head.
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