Journal
MEDICAL MYCOLOGY
Volume 53, Issue 8, Pages 885-889Publisher
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myv059
Keywords
Antifungal; antibacterial; encapsulate; Cryptococcus neorformans var. grubii; interaction
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Funding
- PNPD-CAPES from Brazil
- FAPERGS [2261-12]
- CNPq [470229/2012-8]
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This study evaluated the synergistic interactions between amphotericin B (AMB) and azithromycin (AZM), daptomycin (DAP), linezolid (LNZ), minocycline (MINO), fluconazole (FLZ), flucytosine (5FC), linezolid (LZD), or tigecycline (TIG) against clinical isolates of Cryptococcus neoformans var. grubii before and after capsule induction. High synergism (> 75%) was observed for the combinations, AMB+ 5FC, AMB+ TIG, AMB+ AZM, AMB+ LZD and AMB+ MINO but only in the strains after capsule induction. The results show that the presence of the capsule may lower theminimum inhibitory concentrations (MICs) of antifungal agents, but antimicrobial activity can be improved by combining antifungal and antibacterial agents.
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