Journal
INSECT SCIENCE
Volume 20, Issue 3, Pages 318-328Publisher
WILEY
DOI: 10.1111/1744-7917.12007
Keywords
aflatoxin; allelochemical; bioactivation; cytochrome P450 monooxygenase; flavone; Helicoverpa zea; imperatorin; mycotoxin; piperonyl butoxide; Trichoplusia ni; visnagin; xanthotoxin
Categories
Funding
- USDA [2002-02723]
- National Natural Science Foundation of China [31070388, 31028018]
- National 973 project of China [2011CB100400]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
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Trichoplusia ni caterpillars are polyphagous foliage-feeders and rarely likely to encounter aflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus flavus and A. parasiticus, in their host plants. To determine how T. ni copes with AFB1, we evaluated the toxicity of AFB1 to T. ni caterpillars at different developmental stages and found that AFB1 tolerance significantly increases with larval development. Diet incorporation of AFB1 at 1g/g completely inhibited larval growth and pupation of newly hatched larvae, but 3g/g AFB1 did not have apparent toxic effects on larval growth and pupation of caterpillars that first consume this compound 10days after hatching. Piperonyl butoxide, a general inhibitor of cytochrome P450 monooxygenases (P450s), reduced the toxicity of AFB1, suggesting that AFB1 is bioactivated in T. ni and this bioactivation is mediated by P450s. Some plant allelochemicals, including flavonoids such as flavones, furanocoumarins such as xanthotoxin and imperatorin, and furanochromones such as visnagin, that induce P450s in other lepidopteran larvae ameliorated AFB1 toxicity, suggesting that P450s are also involved in AFB1 detoxification in T. ni.
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