Journal
INSECT MOLECULAR BIOLOGY
Volume 19, Issue 2, Pages 185-193Publisher
WILEY
DOI: 10.1111/j.1365-2583.2009.00967.x
Keywords
cytochrome P450 monooxygenases; CYPs; Aedes aegypti; mosquitoes; gene induction; xenobiotics; detoxification; insecticides
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Funding
- French National Research Agency (Agence Nationale de la Recherche, ANR 'Sante-Environnement Sante-travail') [07SEST014]
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Transcription profiles of 11 Aedes aegypti P450 genes from CYP6 and CYP9 subfamilies potentially involved in xenobiotic metabolism were investigated. Many genes were preferentially transcribed in tissues classically involved in xenobiotic metabolism including midgut and Malpighian tubules. Life-stage transcription profiling revealed important variations amongst larvae, pupae, and adult males and females. Exposure of mosquito larvae to sub-lethal doses of three xenobiotics induced the transcription of several genes with an induction peak after 48 to 72 h exposure. Several CYP genes were also induced by oxidative stress and one gene strongly responded to 20-hydroxyecdysone. Overall, this study revealed that these P450s show different transcription profiles according to xenobiotic exposures, life stages or sex. Their putative chemoprotective functions are discussed.
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