Journal
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 52, Issue -, Pages 60-68Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2014.06.009
Keywords
E93; Methoprene tolerant; Kruppel homolog 1; Broad complex; Insect metamorphosis; Juvenile hormone; Ecdysone
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Funding
- Spanish MICINN [CGL2008-03517/BOS]
- MINECO [CGL2012-36251]
- CSIC (Formosa program) [2010TW0019]
- Brazil Government (Processo CNPQ) [24574812012-L]
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Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Kruppel homolog 1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is Methoprene-tolerant (Met), the latter being the JH receptor in hemimetabolan and holometabolan species. As such, the Met - Kr-h1 - E93 pathway (hereinafter named MEKRE93 pathway) appears to be central to the status quo action of JH, which switch adult morphogenesis off and on in species ranging from cockroaches to flies. The decrease in Kr-h1 mRNA and the rise of E93 expression that triggers adult morphogenesis occur at the beginning of the last instar nymph or in the prepupae of hemimetabolan and holometabolan species, respectively. This suggests that the hemimetabolan last nymph (considering the entire stage, from the apolysis to the last instar until the next apolysis that gives rise to the adult) is ontogenetically homologous to the holometabolan pupa (also considered between two apolyses, thus comprising the prepupal stage). (C) 2014 Elsevier Ltd. All rights reserved.
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