Decavanadate contribution to vanadium biochemistry: In vitro and in vivo studies

Although the number of papers about decavanadate'' has increased in the last decade in vivo or/and cellular toxicological studies involving vanadium that takes in account the contribution of decavanadate (V-10) ion species to biological responses are scarce. These innovative in vivo studies are supported by the fact that decavanadate interact with major proteins such as myosin, actin and Ca2+-ATPase and affect mitochondria function besides induces changes in several cellular antioxidants markers. These recent findings, that are now briefly reviewed, suggested that the biological responses induced by vanadium, will be dependent on vanadium ion species such as decavanadate. Putting it all together, it is clearly shown that decavanadate can be involved in many cellular processes, and therefore it must be taken in account for the understanding the role of vanadium in biological systems. (C) 2013 Elsevier B.V. All rights reserved.