Journal
INORGANICA CHIMICA ACTA
Volume 402, Issue -, Pages 133-139Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2013.04.003
Keywords
Ferrocene; DNA binding constant; Antioxidant
Categories
Funding
- Higher Education Commission Islamabad Pakistan
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We have reported a one pot synthesis of three new ferrocene incorporated selenoureas namely; 1-(2-fluorobenzoyl)-3-(4-ferrocenyl-3-methylphenyl)selenourea (MeP2F), 1-(3-fluorobenzoyl)-3-(4-ferrocenyl-3-methylphenyl)selenourea (MeP3F) and 1-(4-fluorobenzoyl)-3-(4-ferrocenyl-3-methylphenyl)selenourea (MeP2F) by the reaction of corresponding carboxylic acid chlorides with potassium selenocyanate (KSeCN) and 3-methyl-4-ferrocenyl aniline in acetone under constant stirring. Synthesized compounds were characterized by FTIR, NMR (H-1 and C-13), CHNS and AAS. We have also presented X-rays single crystal structure for MeP2F. DNA binding studies were evaluated with the help of cyclic voltammetry in the presence of TBAP (tertiary butyl ammonium perchlorate) as supporting electrolyte in DMSO/water mixture of 70:30. Binding constant for MeP2F is 1.499 x 10(3) M (1), MeP3F is 1.706 x 10(3) M (1) and MeP4F is 1.035 x 10(3) M (1). Binding site size for MeP2F (0.334 bp) < MeP4F (0.410 bp) < MeP3F (0.463 bp). In all the compounds diffusion coefficients of drug-DNA adduct is lower than the free drug indicating slow diffusion of comparatively high molecular weight drug towards the electrode in cyclic voltammetry. Mode of interaction has further been reconfirmed with the help of viscometry. All the three compounds have good antioxidant activities against DPPH with IC50 values of 132, 108 and 84 mu g/ml for MeP2F, MeP4F and MeP3F respectively. (C) 2013 Elsevier B.V. All rights reserved.
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