Journal
INORGANICA CHIMICA ACTA
Volume 394, Issue -, Pages 146-151Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2012.07.002
Keywords
Platinum complexes; Gold complexes; Crystal structure; Electrospray mass spectrometry; Biological activity
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Funding
- University of Waikato
- Asia 2000 Foundation
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Reactions of the dinuclear platinum(II) sulfide complex [Pt-2(mu-S)(2)(PPh3)(4)] with a range of gold(III) dichloride complexes [AuLCl2] containing C, N- or N, N-cycloaurated ligands L gives a new series of dicationic adducts [Pt-2(mu-S)(2)(PPh3)(4)AuL](2+), isolated as their PF6 salts. The complexes investigated are [Au{C-6-H-4(CH2NMe2)-2}Cl-2], [Au{C6H3(CH2NMe2)-2-(OMe)-5}Cl-2], [Au{NC5H4(CH2C6H4)-2}Cl-2], [Au{NC5H4(COC6H4)-2}Cl-2] and [Au{NC5H4(CONH)-2}Cl-2]. An X-ray structure determination on the picolinamide-derived complex [Pt-2(mu-S)(2)(PPh3)(4)Au{NC5H4(CONH)-2}](PF6)(2) was not of sufficiently high quality for detailed discussion, but confirmed the atom connectivity. Reactions of [Pt-2(mu-S)(2)(PPh3)(4)] with [AuCl2 (bipy)]PF6 (L = bipy = 2,2'-bipyridine) and [AuCl2(phen)]Cl (L = phen = 1,10-phenanthroline) gives the corresponding tricationic adducts [Pt-2(mu-S)(2)(PPh3)(4)AuL](3+), also isolated as their PF6 salts. The complexes are characterised by NMR spectroscopy, electrospray mass spectrometry and microelemental analyses. Biological assay data of a selection of these new complexes towards the P388 murine leukemia cell line, as well as a range of antimicrobial tests, reveals overall low activity compared to other cycloaurated gold(III) complexes. (C) 2012 Elsevier B. V. All rights reserved.
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