Journal
INORGANICA CHIMICA ACTA
Volume 391, Issue -, Pages 121-129Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2012.05.014
Keywords
Ternary copper(II) complexes Cytotoxicity; DNA-binding properties; Reduce Schiff base; X-ray crystallography; Phenanthroline base
Categories
Funding
- Ministry of Education through National University of Singapore [R143-000-371-112]
- National Natural Science Foundation of China [21001040]
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Three new ternary copper(II) complexes, [Cu-2(phen)(2)(PDIMAla)(H2O)(2)](ClO4)(2)center dot CH3OH (1), [Cu-2(dpq)(2) (PDIMAla)(H2O)(2)](ClO4)(2)center dot CH3OH (2) and [Cu-2(dppq)(2)(PDIMAla)(H2O)(2)](ClO4)(2)center dot CH3OH (3) (phen = 1,10-phenanthroline, dpq = dipyrido[3,2:2',3'-f]quinoxaline, dppz = dipyrido[3,2-a:2',3'-c]phenazine, H2PDI-MAla = N,N'-(p-xylylene)di-alanine acid) have been synthesized and the complex 1 has been structurally characterized by single-crystal X-ray crystallography, spectrometric titrations, ethidium bromide displacement experiments, CD (circular dichroism) spectral analysis and viscosity measurements. The results indicate that the three compounds, especially the complex 3, can strongly bind to calf-thymus DNA (CT-DNA). The intrinsic binding constants K-b of the ternary copper(II) complexes with CT-DNA are 0.38 x 10(5), 1.4 x 10(5) and 7.8 x 10(5) for 1, 2 and 3, respectively. Comparative cytotoxic activities of the copper(II) complexes are also determined by acid phosphatase assay. The results show that the ternary copper(II) complexes have significant cytotoxic activity against the human hepatic (HepG2), human promyelocytic leukemia (HL60) and human prostate (PC3) cell lines. Investigation of antioxidation property show that all the copper(II) complexes have strong scavenging effects for hydroxyl radicals. (C) 2012 Elsevier B.V. All rights reserved.
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