Journal
INORGANICA CHIMICA ACTA
Volume 362, Issue 3, Pages 784-792Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2008.02.050
Keywords
Bioinorganic chemistry; Metallo-supramolecular chemistry; Supramolecular cylinders; Peptide functionalisation; DNA-binding; Artificial nuclease; DNA coiling
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Funding
- EU RTN network [CT-2002-00175]
- University of Birmingham
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Di-nuclear metallo-supramolecular cylinders, based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.
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