Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 36, Issue -, Pages 45-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2013.08.001
Keywords
Mixed-ligand complexes; Calf thymus DNA; Intercalation; pBR322 DNA; MIC data
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Funding
- Science & Engineering Research Board, New Delhi
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Four novel DNA metalloinsertors having imino-oxalato mixed-ligands, of the composition [ML(ox)]Cl-2 (where M = Cu(II), Co(II), Ni(II) and Zn(II); ox = C2O42- and L = N,N'-bis(4-chlorobenzylidene)benzene-1,2-diamine) were synthesized. They were fully characterized by microanalytical data, magnetic susceptibility values, molar conductivity measurements, UV-vis. IR, H-1 NMR, C-13 NMR and EPR techniques. Their geometry was explored and found to have square-planar geometry. Electronic absorption spectroscopy, cyclic voltammetry and viscosity measurements indicate that these mixed-ligand complexes strongly bind to calf thymus DNA, presumably via an intercalation mechanism. Further, DNA cleavage efficacy of these complexes was investigated by gel electrophoresis. The complexes were found to promote the cleavage of pBR322 DNA in the presence of the reluctant, ascorbic acid. The ligand (L) and the mixed-ligand complexes were tested for their efficiency towards antimicrobial activity and their MIC data reveal that all the complexes have strong activity in comparison to the free ligand and standard drugs, ciprofloxacin and fluconazole. (C) 2013 Elsevier B.V. All rights reserved.
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