Journal
MEDICAL ENGINEERING & PHYSICS
Volume 37, Issue 8, Pages 767-776Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2015.05.009
Keywords
Selective laser sintering; Polycaprolactone; beta-Tricalcium phosphate; Bone tissue engineering; Mechanical properties; Degradation; Accelerated ageing
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Funding
- Embark Initiative Postgraduate Research Scholarship
- Irish Research Council
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Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL-beta-tricalcium phosphate (PCL/beta-TCP) powders using selective laser sintering (SLS). Incorporating beta-TCP particles is desirable to promote osteogenesis. The effects of increasing beta-TCP content on the material's mechanical properties and microstructure were evaluated. The wt% of beta-TCP and PCL particle sizes were found to influence material microstructure and mechanical properties, with increasing ceramic content causing a small but significant increase in stiffness but significant reductions in strength. Degradation of materials was achieved using accelerated ageing methods. The influence of beta-TCP content on degradation at 7 weeks was evaluated through changes in mechanical properties and microstructure, and the ceramic particles were found to reduce elastic modulus and increase strength. The results of this study highlight the influence of ceramic content on mechanical properties and degradation behaviour of PCL/beta-TCP SLS materials, and indicate that these changes must be considered in the design of scaffolds for critical-sized defects. (C) 2015 IPEM. Published by Elsevier Ltd. All rights reserved.
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