Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 13, Issue 4, Pages 537-539Publisher
ELSEVIER
DOI: 10.1016/j.inoche.2010.01.031
Keywords
Fluorinated porphyrin; DNA cleavage; Photodynamic therapy; Ruthenium
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Funding
- Merck Institute for Science Foundation
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Two ruthenium substituted porphyrins differing only by the substitution of a mesopentafluorophenyl group show drastically different DNA photocleavage results. The incorporation of the pentafluorophenyl group provides greater photodynamic efficiency and in addition is capable of causing DNA cleavage in the absence of oxygen. (c) 2010 Elsevier B.V. All rights reserved.
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