Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 13, Issue 12, Pages 1421-1424Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2010.08.006
Keywords
Schiff base; Copper (II) complexes; DNA binding; DNA cleavage
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Funding
- Natural Science Foundation of CQ CSTC [2009BB5300]
- Southwest University
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A series of copper (II) complexes a-d with Schiff bases ligands derived from the condensation reactions between 2-pyridinecarboxaldehyde and different polyamines (ethylenediamine, diethylenetriamine, triethylenetetramine and tetraethylenepentamine) were synthesized and characterized by elemental analysis. FT-IR spectroscopy, HRMS, molar conductance and molecular modeling studies. The interactions of the copper complexes a-d with DNA were investigated by the UV spectra, viscosity measurements and gel electrophoresis under physiological conditions. The experimental results indicated that four complexes could bind to DNA via an intercalative mode and showed a different DNA cleavage activity with the sequence: d>c>a>b. (C) 2010 Elsevier B.V. All rights reserved.
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