Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 12, Issue 8, Pages 704-706Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2009.05.020
Keywords
Rare earth; Schiff-base; X-ray crystallography; Calf thymus DNA binding properties; Antioxidation
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Funding
- National Natural Science Foundation of China [20475023]
- Gansu NSF [3ZS 041-A25-016]
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Nd(III) and four Schiff-base ligands can form binuclear nine-coordination [NdL1-4(NO3)(DMF)(2)](2) complexes with 1:1 metal-to-ligand stoichiometry at Nd(III) center. All the ligands and Nd(III) complexes may be used as potential anticancer drugs, binding to Calf thymus DNA through intercalations with the binding constants at the order of magnitude 10(5)-10(6) M-1. In addition, Nd(III) complexes present stronger affinities to DNA than ligands. All the ligands and Nd(III) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals. (C) 2009 Elsevier B.V. All rights reserved.
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