Journal
INORGANIC CHEMISTRY
Volume 53, Issue 4, Pages 1900-1915Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic401587r
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Funding
- U.S. National Cancer Institute [R01-CA126642]
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Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO(2), and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
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