4.7 Article

Water-Soluble Tb3+ and Eu3+ Complexes with Ionophilic (Ionically Tagged) Ligands as Fluorescence Imaging Probes

Journal

INORGANIC CHEMISTRY
Volume 52, Issue 17, Pages 10199-10205

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ic4017678

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Funding

  1. CAPES
  2. FAPDF
  3. FINA-TEC
  4. CNPq (INCT-Inami and INCT-Catalysis)
  5. FACEPE [APT-0859-1.06/08]
  6. FAPITEC-SE
  7. DPP-UnB

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This article describes a straightforward and simple synthesis of ionically tagged water-soluble Eu3+ and Tb3+ complexes (with ionophilic. ligands) applied for bioimaging of invasive mammal cancer cells (MDA-MB-;23 1). Use. of the task specific ionic. liquid 1-methyl-3-Cirboxymethyl imidazoliurn chloride : (MAT Cl) as the ionophilic. ligand tagged). proved to be a simple, elegant, and efficient Strategy to obtain highly fluorescent water soluble En(3+) (EuMAI) and Tb3+(TbMAI) complexes, TbMAI showed an intense bright green, fluorescence emission selectively staining endoplasmic: reticulum of MDA-MB=231 cells:

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