Journal
INORGANIC CHEMISTRY
Volume 50, Issue 21, Pages 10519-10521Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic201349s
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Funding
- INCT-Biologia Molecular Estrutural e Bioimagem
- INCT-Catalise
- CNPq
- Capes
- FINEP
- FAPESC
- MCT
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In this report, we demonstrate how UV-light exposure can enhance DNA cleavage promoted by two copper(11) complexes of tetracyclines and 1,10-phenanthroline about 40 times in comparison to nonirradiated conditions. In addition, new aspects regarding their DNA binding properties, as well as the mechanism of the cleavage reaction, were also investigated.
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