Journal
INORGANIC CHEMISTRY
Volume 50, Issue 16, Pages 7412-7420Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic102082k
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Funding
- National Natural Science Funds for Distinguished Young Scholars [20825101]
- National Natural Science Foundation of China [50803028, 20804019]
- Shanghai Sci. Tech. Comm. [1052 nm03400]
- Shanghai Leading Academic Discipline Project [B108, IRT0911]
- Scientific and Technological Activities for Returned Personnel in Nanjing City [NJ209001]
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In this work, a neutral iridium(III) complex [Ir(bt)(2)(acac)] (Hbt = 2-phenylbenzothiazole; Hacac = acetylacetone) has been realized as a Hg(II)-selective sensor through UV-vis absorption, phosphorescence emission, and electrochemical measurements and was further developed as a phosphorescent agent for monitoring intracellular Hg(II). Upon addition of Hg(II) to a solution of [Ir(bt)(2)(acac)], a noticeable spectral blue shift in both absorption and phosphorescent emission bands was measured. H-1 NMR spectroscopic titration experiments indicated that coordination of Hg(II) to the complex induces fast decomposition of [Ir(bt)(2)(acac)] to form a new complex, which is responsible for the significant variations in optical and electrochemical signals. Importantly, cell imaging experiments have shown that [Ir(bt)(2)(acac)] is membrane permeable and can be used to monitor the changes in Hg(II) levels within cells in a ratiometric phosphorescence mode.
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