Journal
INORGANIC CHEMISTRY
Volume 49, Issue 13, Pages 5792-5794Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic100638u
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Funding
- National Natural Science Foundation of China [20861004]
- National Key New Drug Contrive Project [2009ZX09103-109]
- Provincial Natural Science Foundation of Yunnan [2008CCO20, 2009CD006]
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An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.
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