Journal
INORGANIC CHEMISTRY
Volume 48, Issue 7, Pages 2726-2728Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic9001237
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Funding
- Hellman Faculty Scholar Award
- Beckman Young Investigator Award
- NIH [GM08326]
- NSF [0634989]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0634989] Funding Source: National Science Foundation
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We describe the metal-dependent self-assembly of symmetrical protein homooligomers from protein building blocks that feature appropriately engineered metal-chelating motifs on their surfaces. Crystallographic studies indicate that the same four-helix-bundle protein construct, MBPC-1, can self-assemble into C-2 and C-3 symmetrical assemblies dictated by Cu-II and Ni-II coordination, respectively. The symmetry inherent in metal coordination can thus be directly applied to biological self-assembly.
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