Journal
MEDIATORS OF INFLAMMATION
Volume 2015, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2015/620581
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Funding
- Research Foundation Flanders (FWO)
- Concerted Research Actions (GOA) of Ghent University
- Belgian Science Policy (Interuniversity Attraction Pools) [IAP7/07]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [ON173056]
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Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shownthat neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases(MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro) inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.
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