Journal
INNATE IMMUNITY
Volume 24, Issue 6, Pages 335-348Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425918789255
Keywords
Platelet; inflammation; infection; Kupffer cell; neutrophils; macrophages
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [DE 2654/1-1]
- Canadian Institute of Health Research (CIHR)
- Alberta Innovates Health Solutions (AIHS)
- Heart and Stroke Foundation of Canada
- Canada Research Chairs programme
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Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platelets form complexes with neutrophils to modulate their capacities to produce reactive oxygen species or form neutrophil extracellular traps. Furthermore, they release microbicidal factors and cytokines that kill pathogens and influence the immune response, respectively. Platelets also maintain the vascular integrity during inflammation by a mechanism that is different from classical platelet activation. In this review we summarize the current knowledge about how platelets interact with the innate immune system during inflammation and infection and highlight recent advances in the field.
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