Journal
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Volume 44, Issue -, Pages S28-S33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0020-1383(13)70007-X
Keywords
Scaffolds; Bone regeneration; Preclinical studies; Clinical applications
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Scaffolds are extensively used in surgery to replace missing bone and to achieve bony union and fusion. An ideal scaffold should not only maintain, induce, and restore biological functions where cells, extracellular matrix, and growth factors are needed, but also have the right properties with respect to degradation, cell binding, cellular uptake, non-immunogenicity, mechanical strength, and flexibility. Here we examine both the basic science behind the development of scaffolds and comprehensively and systematically review the clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.
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