Journal
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Volume 42, Issue 6, Pages 574-579Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.injury.2011.03.034
Keywords
Growth factors; Fracture healing; Bone regeneration; Bone morphogenetic proteins; Bone defects; Non-union; Platelet-rich plasma; Platelet-derived growth factor; Fibroblast growth factor; Vascular endothelial growth factor
Funding
- Stryker Biotech
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A large body of research has investigated the use of growth factors for bone regeneration, as a potential alternative to autogenous bone grafting. The bone morphogenetic proteins (BMPs) represent the most extensively investigated growth factors to date, as potential therapeutic agents for bone regeneration. Despite decades of research, the ideal growth factor or combination of growth factors for bone regeneration remains undefined. This article reviews the current available evidence for the application of growth factors for bone regeneration, with a focus on the clinical evidence for BMP use. Emerging preclinical and clinical evidence for growth factors other than the BMPs is also discussed. (C) 2011 Elsevier Ltd. All rights reserved.
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