Journal
MEDIATORS OF INFLAMMATION
Volume 2015, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2015/158956
Keywords
-
Categories
Funding
- Fund for Scientific Research-Flanders, Belgium (FWO-Vlaanderen) [G.0168.09]
- Special Research Fund (BOF)
- BOF-GOA [ID PS 28313]
- Medical Legacy Fund (UZA)
- Methusalem Funding Program
- Belgian Hercules Foundation
- Belgian Charcot Foundation
- Belgische Stichting Roeping
- Flemish Institute for Science and Technology (IWT)
- Fund for Scientific Research (FWO) Flanders
Ask authors/readers for more resources
In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent evidence suggests a role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of one combined endurance/resistance exercise bout on the number and function of DC in MS patients and healthy controls. Our results show a rapid increase in the number of DC in response to physical exercise in both MS patients and controls. Further investigation revealed that in particular DC expressing the migratory molecules CCR5 and CD62L were increased upon acute physical activity. This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 following one exercise bout. Circulating DC display reduced TLR responsiveness after acute exercise, as evidenced by a less pronounced upregulation of activation markers, HLA-DR and CD86, on plasmacytoid DC and conventional DC, respectively. Our results indicate mobilization of DC, which may be less prone to drive inflammatory processes, following exercise. This may present a negative feedback mechanism for exercise-induced tissue damage and inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available