Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 145, Issue -, Pages 13-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2015.01.002
Keywords
Telomere length; Mitochondrial haplogroups; Aging; Latvians
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Funding
- European Social Fund (ESF) [2013/0039/1DP/1.1.1.2.0/13/APIA/VIAA/038]
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Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geographic location, and/or specific historic background. The aims of this study were to identify a specific hg which correlates with aging in a Latvian populating and to evaluate the possible association of TL variability with specific mitochondrial hgs. The results show no significant correlation between TL, mitochondrial DNA hgs and longevity. A slight increase in frequency was observed among centenarians of hg H; however, these findings were not statistically significant. TL did not show any statically significant difference, only hg W had slightly longer telomeres among others. An insignificant increase in TL was observed in the 55-89 age group of hg W but in the <90 age group for hg J which also had the longest TL in the 20-45 age group. In conclusion this study indicates that specific mitochondrial DNA hgs do not have a significant, if any, influence on the variation of TL in Latvians. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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