Journal
INHALATION TOXICOLOGY
Volume 23, Issue 1, Pages 1-10Publisher
INFORMA HEALTHCARE
DOI: 10.3109/08958378.2010.535572
Keywords
Diesel engine exhaust; endothelium; gene expression; microarray; apolipoprotein E; hypercholesterolemia; air pollution
Categories
Funding
- NIEHS [ES013395]
- NCRR [RR016453]
- NHLBI [HL073449]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016453] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [UH1HL073449] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES013395, R01ES014639] Funding Source: NIH RePORTER
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Objective: To examine the in vivo effects of subchronic diesel exhaust exposure on endothelial cell transcriptional responses in the presence of hypercholesterolemia. Methods: ApoE (-/-) and ApoE (+/+) mice inhaled diesel exhaust diluted to particulate matter levels of 300 or 1000 mu g/m 2.8-fold in the endothelium of ApoE (-/-) mice receiving diesel exhaust at 300 or 1000 mu g/m
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