Journal
INHALATION TOXICOLOGY
Volume 20, Issue 12, Pages 1093-1100Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08958370802130379
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Funding
- National Institute for Occupational Safety and Health (NIOSH) [R01 OH003900]
- U. S. EPA [916716]
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [R01OH003900] Funding Source: NIH RePORTER
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Numerical simulations have been carried out on a model of the right passageway of an anonymous, adult male's nasal cavity, constructed from magnetic resonance imagery (MRI) scans. Steady, laminar, inspiratory flow was assumed to simulate inhalation. Analysis shows smoothly varying streamlines with a peak in velocity magnitude occurring in the nasal valves and a peak in vorticity magnitude immediately posterior. Dilute, uniform concentrations of inertial (1 mu m <= d(ae) <= 10 mu m) particles were released at the nostril and tracked via a Lagrangian tracking algorithm. Deposition efficiency is shown to increase with particle size and flow rate. Preferential deposition is seen in the anterior third of the nasal cavity for large Stokes number particles. An empirical expression for particle deposition is proposed that incorporates particle size, flow rate, and nose anatomy.
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