Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 8, Issue 6, Pages 646-653Publisher
WILEY-BLACKWELL
DOI: 10.1111/irv.12289
Keywords
H5N8; highly pathogenic avian influenza virus; wild duck
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Funding
- Department of Wildlife Conservation and Nature Reserve Management of the State Forestry Administration, China
- Chinese Ministry of Science and Technology [KJYJ-2013-01-01, 2013BAD12B04]
- 863 program [2012AA022006]
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Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.
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