Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 8, Issue 3, Pages 384-388Publisher
WILEY
DOI: 10.1111/irv.12230
Keywords
H5N1; hemagglutinin; highly pathogenic avian influenza; molecular epidemiology; nomenclature; phylogenetics; viral evolution
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Funding
- Australian Government Department of Health and Ageing
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The divergence of the hemagglutinin gene of A/goose/Guangdong/1/1996-lineage H5N1 viruses during 2011 and 2012 (807 new sequences collected through December 31, 2012) was analyzed by phylogenetic and p-distance methods to define new clades using the pre-established nomenclature system. Eight new clade designations were recommended based on division of clade 1 center dot 1 (Mekong River Delta), 2 center dot 1 center dot 3 center dot 2 (Indonesia), 2 center dot 2 center dot 2 (India/Bangladesh), 2 center dot 2 center dot 1 center dot 1 (Egypt/Israel), and 2 center dot 3 center dot 2 center dot 1 (Asia). A simplification to the previously defined criteria, which adds a letter rather than number to the right-most digit of fifth-order clades, was proposed to facilitate this and future updates.
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