Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 7, Issue -, Pages 18-23Publisher
WILEY
DOI: 10.1111/irv.12176
Keywords
Antiviral; influenza; neuraminidase inhibitor; oseltamivir; resistance; zanamivir
Categories
Funding
- Roche
- GlaxoSmithKline
- Biota on the topic of influenza treatment
Ask authors/readers for more resources
Neuraminidase inhibitors (NAIs) are first-line agents for the treatment and prevention of influenza virus infections. As for other antivirals, the development of resistance to NAIs has become an important concern particularly in the case of A(H1N1) viruses and oseltamivir. The most frequently reported change conferring oseltamivir resistance in that viral context is the H275Y neuraminidase mutation (N1 numbering). Recent studies have shown that, in the presence of the appropriate permissive mutations, the H275Y variant can retain virulence and transmissibility in some viral backgrounds. Most oseltamivir-resistant influenza A virus infections can be managed with the use of inhaled or intravenous zanamivir, another NAI. New NAI compounds and non-neuraminidase agents as well as combination therapies are currently in clinical evaluation for the treatment for severe influenza infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available