Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 8, Issue 1, Pages 1-7Publisher
WILEY
DOI: 10.1111/irv.12196
Keywords
Excess mortality; H1N1pdm09; impact; influenza; pandemic
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Funding
- Harvard Center for Communicable Disease Dynamics, National Institute of General Medical Sciences [U54 GM088558]
- Area of Excellence Scheme of the University Grants Committee of Hong Kong [AoE/M-12/06]
- US National Institutes of Health [1K01 AI101010-01]
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Hong Kong experienced two large epidemics of pandemic influenza A(H1N1pdm09). We used regression methods to estimate the excess mortality associated with each epidemic. The first epidemic of H1N1pdm09 peaked in September 2009 and was associated with 213 [95% confidence interval (CI): -808, 1182] excess all-cause deaths per 100000 population. The second epidemic of H1N1pdm09 in early 2011 was associated with 472 [95% CI: -070, 1050] excess deaths per 100000 population. More than half of the estimated excess all-cause deaths were attributable to respiratory causes in each epidemic. The reasons for substantial impact in the second wave remain to be clarified.
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