Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 7, Issue 5, Pages 854-862Publisher
WILEY-BLACKWELL
DOI: 10.1111/irv.12094
Keywords
Influenza; interferon; low dose; oromucosal
Categories
Funding
- State Health Research Advisory Council Research Translation Projects, an initiative of the Western Australian Department of Health
Ask authors/readers for more resources
Background and objectiveInterferon alpha (IFN) is a known antiviral agent. A double-blind, placebo-controlled clinical trial was conducted investigating the use of low-dose oral interferon alpha for preventing acute viral respiratory illnesses. MethodsTwo hundred healthy adults aged 18-75years were enrolled and completed weekly health data questionnaires to monitor for symptoms and impact of respiratory illness. Serum samples were tested for antibodies against influenza and other common respiratory viruses. ResultsLow-dose oral IFN prophylaxis did not reduce the incidence or impact of acute respiratory illness (ARI) or the impact of illness on daily activities. Post hoc analysis of participant subgroups, however, identified significant reductions in the incidence of ARI reported by males, those aged 50years or more and those who received the 2009 seasonal influenza vaccine. Interferon alpha prophylaxis had a significant impact on the reporting of moderate-to-severe feverishness by the study population. Seropositive participants in the IFN group were more likely to report asymptomatic or mild symptoms compared with those in the placebo group who were more likely to report stronger symptoms. ConclusionsLow-dose oral IFN prophylaxis was not effective in limiting the overall incidence of ARI in our study population. However, there was evidence that prophylaxis reduced the severity of symptoms and had a beneficial effect in some subpopulations, including those who received the 2009 seasonal trivalent influenza vaccination.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available