Journal
INFLAMMATORY BOWEL DISEASES
Volume 20, Issue 1, Pages 166-175Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MIB.0b013e3182a69dca
Keywords
macrophages; dendritic cells; IBD; inflammation
Categories
Funding
- NIH NIDDK [F30 DK089692, R01 DK054452]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK054452, F30DK089692] Funding Source: NIH RePORTER
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In the healthy gastrointestinal tract, homeostasis is an active process that requires a careful balance of host responses to the enteric luminal contents. Intestinal macrophages and dendritic cells (DCs) comprise a unique group of tissue immune cells that are ideally situated at the interface of the host and the enteric luminal environment to appropriately respond to microbes and ingested stimuli. However, intrinsic defects in macrophage and DC function contribute to the pathogenesis of inflammatory bowel diseases, as highlighted by recent genome-wide association studies. Gastrointestinal macrophages and DCs participate in inflammatory bowel disease development through inappropriate responses to enteric microbial stimuli, inefficient clearance of microbes from host tissues, and impaired transition from appropriate proinflammatory responses to anti-inflammatory responses that promote resolution. By understanding how intestinal macrophages and DCs initiate chronic inflammation, new pathogenesis-based therapeutic strategies to treat human inflammatory bowel diseases will be elucidated.
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