Journal
INFLAMMATORY BOWEL DISEASES
Volume 18, Issue 7, Pages 1356-1363Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.22839
Keywords
ulcerative colitis; bowel damage; complications of IBD
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Funding
- International Organization for the study of Inflammatory Bowel Disease (IOIBD)
- Burril B. Crohn Research Foundation
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In the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long-term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined. (Inflamm Bowel Dis 2011;)
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