Journal
INFLAMMATORY BOWEL DISEASES
Volume 18, Issue 1, Pages 94-100Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21742
Keywords
ulcerative colitis; colorectal cancer; microRNA
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Funding
- University of Chicago, Institute of Translational Medicine
- Crohn's and Colitis Foundation of America
- Crohn's Disease Working Group
- Gastrointestinal Research Foundation of Chicago
- University of Chicago, Comprehensive Cancer Center
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK042086, K08DK090152] Funding Source: NIH RePORTER
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Background: miR-143 and miR-145 are believed to function as colon cancer tumor suppressors, as they inhibit colon cancer cell growth and are downregulated in sporadic colonic tumors. We speculated that miR-143 and miR-145 might also be downregulated and contribute to malignant transformation of colonic epithelium in longstanding ulcerative colitis (UC).
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