Journal
INFLAMMATORY BOWEL DISEASES
Volume 18, Issue 1, Pages 63-73Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21676
Keywords
hypoxanthine guanine phosphoribosyltransferase (HPRT); thiopurine S-methyltransferase (TPMT); 6-thioguanine nucleotides (6-TGNs); thiopurine drug; inflammatory bowel disease (IBD)
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Funding
- Science and Technology Ministry of China [2009ZX09304-003]
- National Nature Science Fund of China [30572231, 30873124, 30873125]
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Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well known. This study investigated the effects of TPMT and hypoxanthine guanine phosphoribosyltransferase (HPRT) activities on 6-thioguanine nucleotides (6-TGNs) concentrations and thiopurine-induced leukopenia in patients with IBD.
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