Journal
INFLAMMATORY BOWEL DISEASES
Volume 17, Issue 4, Pages 1021-1029Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21426
Keywords
metabolomic; metabonomic; metabolite profiling; Crohn's disease; ulcerative colitis
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Funding
- Foundation for Research, Science and Technology [CO6X702]
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Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) attributed to a dysregulated immune response towards intestinal microbiota. Although various susceptibility genes have been identified for CD and UC, the exact disease etiology is unclear and complicated by the influence of environmental factors. Metabolomic analysis enables high sample throughput measurements of multiple metabolites in biological samples. The use of metabolomic analysis in medical sciences has revealed metabolite perturbations associated with diseases. This article provides a summary of the current understanding of IBD, and describes potential applications and previous metabolomic analysis in IBD research to understand IBD pathogenesis and improve IBD therapy.
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